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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
[Malignant peritoneal mesothelioma]
V Scripcariu1, Elena Dajbog, L Lefter
1Clinica aIII-a Chirurgicală si Centrul de Cercetare in Chirurgia Oncologică si Training in Chirurgie Generală, Spitalul "Sf. Spiridon", U.M.E "Gr. T. Popa" Iasi. vscripcariu@gmail.com
Abstract:
Mesothelioma is a neoplasm originating from the mesothelial surface lining cells of the serous human cavities. It may involve the pleura, less frequently the peritoneum rarely, the pericardium, the tunica vaginalis testis and ovarian epithelium. Asbestos has been widely used in industry. A causal relationship between asbestos exposure and pleural, peritoneal and pericardial malign mesothelioma was suggested, the risk of cancer being correlated to cumulate exposure. Studies from National Cancer Institute, USA, show that the malignant mesothelioma is a rare and aggressive asbestos related malignancy. The symptomatology is insidious and poses difficult problems in diagnosis and treatment. This paper presents the case of a 59 year old patient with malignant peritoneal mesothelioma who worked almost 40 years as an electrician, exposed to asbestos fibers. He was hospitalized for important weight loss, abdominal pain and tiredness being diagnosed after imaging tests with a giant tumor, localized at the abdominal upper level, which seems to originate from the spleen's superior pole. During surgery we discovered a tumor with cystic parts, intense vascularized, which turn to be adherent in the upper side to the lower face of the left midriff cupola, to the spleen superior pole and 1/3 middle level of the great gastric curve. It was performed surgical ablation of the tumor, splenectomy with favorable postoperative evolution, the patient being now under chemotherapy treatment.
Insights
This case report details a patient with malignant peritoneal mesothelioma, a rare cancer linked to asbestos exposure. Early diagnosis and surgical intervention were crucial for this aggressive asbestos-related malignancy.
Area of Science:
- Oncology
- Pathology
- Epidemiology
Background:
- Mesothelioma is a rare neoplasm arising from mesothelial cells, affecting serous cavities like the pleura and peritoneum.
- Asbestos exposure is a known etiological factor for malignant mesothelioma, with risk correlating to cumulative exposure.
- Malignant mesothelioma is an aggressive cancer with insidious symptoms, complicating diagnosis and treatment.
Observation:
- A 59-year-old male electrician with a 40-year history of asbestos exposure presented with weight loss, abdominal pain, and fatigue.
- Imaging revealed a large tumor in the upper abdomen, apparently originating from the spleen's superior pole.
- Surgical exploration identified a vascularized, cystic tumor adherent to the diaphragm, spleen, and stomach.
Findings:
- Surgical ablation of the tumor and splenectomy were performed.
- The patient experienced a favorable postoperative recovery.
- The patient is currently undergoing chemotherapy for malignant peritoneal mesothelioma.
Implications:
- This case highlights the importance of considering asbestos exposure in patients with unexplained abdominal malignancies.
- Aggressive surgical management combined with adjuvant chemotherapy can be effective for malignant peritoneal mesothelioma.
- Further research into the long-term outcomes and optimal treatment strategies for peritoneal mesothelioma is warranted.

