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Intranodal palisaded myofibroblastoma.
Thong Nguyen1, Mahmoud A Eltorky
1Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0743, USA. thonguye@utmb.edu
Archives of Pathology & Laboratory Medicine
|February 8, 2007
Summary
Intranodal palisaded myofibroblastoma (IPM) is a rare inguinal mass. Surgical treatment offers an excellent prognosis with a low recurrence rate and no malignant transformation.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Intranodal palisaded myofibroblastoma (IPM) typically manifests as a slow-growing, painless inguinal mass.
- IPM predominantly affects individuals aged 45–55, with a 2:1 male-to-female ratio and no specific ethnic predilection.
Purpose of the Study:
- To review and synthesize the clinicopathological features, diagnostic criteria, and treatment outcomes of Intranodal palisaded myofibroblastoma (IPM).
Main Methods:
- A comprehensive literature review of 42 cases of IPM across 13 publications.
- Analysis of gross, microscopic, immunohistochemical, and electron microscopic findings.
- Evaluation of treatment outcomes, including recurrence rates and malignant transformation.
Main Results:
- Gross examination reveals hemorrhage within the tumor.
- Microscopic hallmarks include peripheral lymphoid tissue, spindle cells with nuclear palisading, hemorrhage, amianthoid fibers, and fuchsinophilic bodies.
- Immunohistochemistry shows positivity for smooth muscle actin and cyclin D1, with a low Ki-67 proliferation index.
Conclusions:
- IPM is characterized by specific histopathological and immunohistochemical features.
- Surgical intervention leads to an excellent prognosis, with a low recurrence rate (approximately 6%) and no reported cases of malignant transformation.
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