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Are aortic aneurysms caused by atherosclerosis?

D Reed1, C Reed, G Stemmermann

  • 1Honolulu Heart Program, HI 96817.

Circulation
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Atherosclerosis risk factors like high blood pressure, cholesterol, and smoking are linked to most aortic aneurysms. This 20-year study suggests atherosclerosis is a key factor in aneurysm development.

Area of Science:

  • Cardiovascular Medicine
  • Epidemiology
  • Pathology

Background:

  • Investigated the controversial role of atherosclerosis in aortic aneurysm development.
  • Utilized 20-year follow-up data from over 8,000 Japanese-ancestry men in Hawaii.

Purpose of the Study:

  • To examine the relationship between atherosclerosis risk factors and the incidence of aortic aneurysms and dissections.
  • To determine if atherosclerosis is a necessary component in the causal pathway of aortic aneurysms.

Main Methods:

  • Analysis of clinical incident events (aortic aneurysms and dissections) and autopsy data.
  • Identified baseline risk factors for aortic atherosclerosis and aneurysms.
  • Compared risk factors for aortic aneurysms versus aortic dissections.

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Main Results:

  • Identified 151 aortic aneurysms and 23 aortic dissections among 174 clinical events.
  • Baseline risk factors for aortic aneurysms (hypertension, high cholesterol, smoking) mirrored those for aortic atherosclerosis.
  • These risk factors were also associated with aortic aneurysms in autopsied men.
  • Aortic dissections showed an age-specific incidence, suggesting innate susceptibility and other precipitating factors, primarily predicted by hypertension.

Conclusions:

  • Atherosclerosis risk factors are likely necessary for the development of the majority of aortic aneurysms in this cohort.
  • Atherosclerosis itself appears to be a critical element in the causal pathway for most aortic aneurysms.
  • Findings have implications for the prevention of aortic aneurysms by targeting atherosclerosis.