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Published on: April 22, 2022
Caffeinated beverage intake and the risk of heart disease mortality in the elderly: a prospective analysis
James A Greenberg1, Christopher C Dunbar, Roseanne Schnoll
1Brooklyn College of the City University of New York, New York, NY 11210, USA. jamesg@brooklyn.cuny.edu
Insights
Caffeinated beverage consumption may reduce heart disease mortality in older adults. This protective effect was observed in individuals not severely hypertensive, suggesting a potential benefit for elderly cardiovascular health.
Area of Science:
- Epidemiology
- Cardiovascular Health
- Gerontology
Background:
- Aging increases the risk of cardiovascular events, potentially exacerbated by postprandial hypotension.
- Caffeine's potential to mitigate these risks in the elderly warrants investigation.
Purpose of the Study:
- To determine if caffeinated beverage consumption is associated with a reduced risk of cardiovascular disease (CVD) mortality in older adults.
- To analyze prospective cohort data to test this hypothesis.
Main Methods:
- Prospective cohort study involving 6594 participants aged 32-86 years.
- Cox regression analyses were used to assess CVD mortality over an 8.8-year follow-up period.
- Data from the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study were utilized.
Main Results:
- Higher intake of caffeinated beverages was linked to a lower relative risk of CVD and heart disease mortality in participants aged 65 years and older.
- A significant dose-response relationship was observed, with greater consumption correlating with reduced mortality risk (P for trend = 0.003).
- The protective effect was primarily noted in individuals who were not severely hypertensive and was not significant for cerebrovascular disease mortality.
Conclusions:
- Habitual consumption of caffeinated beverages appears to offer protection against heart disease mortality in elderly individuals.
- This finding suggests a potential role for caffeine in supporting cardiovascular health in aging populations.
Background:
Motivated by the possibility that caffeine could ameliorate the effect of postprandial hypotension on a high risk of coronary events and mortality in aging, we hypothesized that caffeinated beverage consumption decreases the risk of cardiovascular disease (CVD) mortality in the elderly.
Objective:
The objective of the study was to use prospective cohort study data to test whether the consumption of caffeinated beverages exhibits this protective effect.
Design:
Cox regression analyses were conducted for 426 CVD deaths that occurred during an 8.8-y follow-up in the prospective first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. The analysis involved 6594 participants aged 32-86 y with no history of CVD at baseline.
Results:
Participants aged >or=65 y with higher caffeinated beverage intake exhibited lower relative risk of CVD and heart disease mortality than did participants with lower caffeinated beverage intake. It was a dose-response protective effect: the relative risk (95% CI) for heart disease mortality was 1.00 (referent), 0.77 (0.54, 1.10), 0.68 (0.49, 0.94), and 0.47 (0.32, 0.69) for <0.5, 0.5-2, 2-4, and >or=4 servings/d, respectively (P for trend = 0.003). A similar protective effect was found for caffeine intake in mg/d. The protective effective was found only in participants who were not severely hypertensive. No significant protective effect was found in participants aged <65 y or in cerebrovascular disease mortality for those aged >or=65 y.
Conclusion:
Habitual intake of caffeinated beverages provided protection against the risk of heart disease mortality among elderly participants in this prospective epidemiologic analysis.
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