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Updated: Jul 17, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Cutaneous sarcomatoid B-cell lymphoma.

Savita Ries¹, Ronald Barr, Philip LeBoit

¹Department of Pathology, Memorial Medical Center of Long Beach, Long Beach, CA, USA. sries@memorialcare.org

The American Journal of Dermatopathology

|February 8, 2007

Summary

A rare spindle cell B-cell lymphoma presented as a scarlike plaque, mimicking fibromucinosis. This case highlights the importance of considering sarcomatoid B-cell lymphomas in difficult spindle cell diagnoses.

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Last Updated: Jul 17, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Area of Science:

Dermatopathology
Oncology
Immunohistochemistry

Background:

Spindle cell (sarcomatoid) B-cell lymphomas are rare cutaneous neoplasms.
Cutaneous sarcomatoid lymphomas typically present as tumors, but variants can mimic other lesions.

Observation:

A 48-year-old male presented with a scarlike plaque on the scalp, initially diagnosed as atypical fibromucinosis.
Microscopic examination revealed a prominent myxoid matrix, complicating the initial diagnosis.
Immunohistochemistry was crucial in differentiating from other spindle cell neoplasms and fibromucinous lesions.

Findings:

The lesion showed negative staining for markers of carcinoma, melanoma, and histiocytic tumors.
Strong positive staining for LCA (CD45RB) and CD20 confirmed a B-cell lymphoma diagnosis.
The patient achieved complete resolution after local radiotherapy.

Implications:

This case underscores the necessity of including rare sarcomatoid B-cell lymphomas in the differential diagnosis of unusual spindle cell proliferations.
Recognizing these rare variants, even when presenting as fibromucinosis-like lesions, is critical for accurate diagnosis and treatment.
The findings expand the spectrum of presentations for cutaneous sarcomatoid B-cell lymphomas.