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Related Experiment Videos

Stress-induced insulin resistance: recent developments.

Mattias Soop1, Jonas Nygren, Anders Thorell

  • 1Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge, Sweden.

Current Opinion in Clinical Nutrition and Metabolic Care
|February 8, 2007
PubMed
Summary
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Intensive insulin therapy in ICUs has minor clinical relevance despite hypoglycemia risks. Perioperative measures like carbohydrate treatment and laparoscopy improve surgical outcomes by reducing metabolic derangements.

Area of Science:

  • Endocrinology
  • Metabolic Medicine
  • Surgical Science

Background:

  • Growing interest in stress-induced insulin resistance.
  • Recent clinical and mechanistic investigations reviewed.

Purpose of the Study:

  • Review recent clinical and mechanistic investigations on stress-induced insulin resistance.
  • Evaluate intensive insulin therapy and perioperative interventions.

Main Methods:

  • Review of recent clinical trials and cohort studies.
  • Analysis of animal and in-vitro research.
  • Evaluation of perioperative interventions in elective surgery.

Main Results:

  • Intensive insulin therapy in ICUs shows high hypoglycemia incidence, but minor clinical relevance.

Related Experiment Videos

  • Glucose control is the primary mechanism of intensive insulin therapy.
  • Intraoperative hyperglycemia correlates with postoperative morbidity; preoperative carbohydrate treatment and laparoscopic surgery show beneficial effects.
  • Conclusions:

    • Improved insulin dosing, administration, and glucose monitoring are needed for intensive insulin therapy.
    • Perioperative measures, including oral carbohydrate treatment and laparoscopic techniques, attenuate metabolic derangements and should be integrated into care protocols to minimize morbidity and enhance recovery.