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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Classification of Illness01:17

Classification of Illness

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Acute illness is severe and...
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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

The development of systemic sclerosis classification criteria.

Jennifer G Walker1, Janet Pope, Murray Baron

  • 1Faculty of Medicine, University of Calgary, 3330 Hospital Dr NW, T2N 4N1, Calgary, AB, Canada.

Clinical Rheumatology
|February 8, 2007
PubMed
Summary

Systemic sclerosis (SSc) classification needs updated criteria for better patient identification and research. Current American College of Rheumatology (ACR) criteria are outdated, lacking sensitivity for limited SSc and newer diagnostic advancements.

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Area of Science:

  • Rheumatology
  • Immunology
  • Connective Tissue Diseases

Background:

  • Systemic sclerosis (SSc) is a rare, debilitating connective tissue disorder with unknown etiology, likely influenced by genetic and environmental factors.
  • Existing disease registries are valuable but hampered by outdated or inadequate classification criteria, complicating registry comparisons and clinical trial patient selection.
  • The 1980 American College of Rheumatology (ACR) criteria for SSc are no longer sufficient due to advancements in understanding autoantibodies and nailfold capillaroscopy, and exhibit low sensitivity for limited SSc.

Purpose of the Study:

  • To highlight the limitations of current Systemic Sclerosis (SSc) classification criteria.
  • To emphasize the need for updated, sensitive, and specific criteria for SSc diagnosis and research.
  • To discuss the potential incorporation of new diagnostic techniques and biomarkers into future SSc classification systems.

Main Methods:

  • Review and analysis of existing Systemic Sclerosis (SSc) classification systems, including the outdated ACR criteria.
  • Discussion of advancements in diagnostic tools such as autoantibody profiling and nailfold capillaroscopy.
  • Exploration of the ongoing debate regarding SSc disease subset models (two vs. three subsets).

Main Results:

  • The current American College of Rheumatology (ACR) criteria for Systemic Sclerosis (SSc) are outdated and lack sensitivity, particularly for limited cutaneous SSc.
  • No single proposed alternative classification system has achieved universal acceptance.
  • There is ongoing debate regarding the optimal disease subset model for SSc.

Conclusions:

  • Development of new, validated classification criteria for Systemic Sclerosis (SSc) is crucial.
  • Future criteria must integrate contemporary diagnostic techniques and biomarkers.
  • Rigorous validation of any new criteria is essential before widespread adoption in research and clinical practice.