Related Experiment Video

Updated: Jul 17, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Atypical papillary glioneuronal tumor

Jesús Vaquero1, Santiago Coca

  • 1Department of Neurosurgery, Puerta de Hierro Hospital, Autonomous University, San Martin de Porres, 4, Madrid 28035, Spain. jvaqueroc@telefonica.net

Journal of Neuro-Oncology
|February 8, 2007
PubMed

Insights

A rare papillary glioneuronal tumor (PGNT) with aggressive features showed favorable outcomes after surgery and radiotherapy. This case highlights that high-grade histological findings in PGNT do not always predict poor prognosis.

Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Pathology

Background:

  • Papillary glioneuronal tumors (PGNTs) are rare primary brain tumors.
  • While typically considered low-grade, some PGNTs exhibit atypical features.
  • Understanding the behavior of atypical PGNTs is crucial for treatment planning.

Observation:

  • A 34-year-old male presented with a 3-month history of headaches.
  • MRI revealed a large cystic tumor in the right frontoparietal lobe.
  • Pathological examination identified a papillary glioneuronal tumor with mitotic activity and a 15% Ki-67 index.

Findings:

  • The patient underwent radical surgery followed by radiotherapy.
  • Five years post-treatment, the patient remains symptom-free with no evidence of recurrence or residual tumor.
  • This outcome suggests a potentially indolent course despite aggressive histological markers.

Implications:

  • This case supports the existence of an atypical PGNT variant with high proliferative activity.
  • Histological indicators of malignancy in PGNTs may not correlate with short-term unfavorable outcomes.
  • Aggressive treatment modalities can be effective even in PGNTs with concerning pathological features.

More Related Videos

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...