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Small animal absorbed radiation dose from serial micro-computed tomography imaging.

Stephanie K Carlson1, Kelly L Classic, Claire E Bender

  • 1Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. scarlson@mayo.edu

Molecular Imaging and Biology
|February 8, 2007
PubMed
Summary

Serial micro-computed tomography (micro-CT) scans deliver low radiation doses to mouse cancer xenografts. These doses are unlikely to impact tumor growth, making micro-CT a safe imaging tool for preclinical research.

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Area of Science:

  • Preclinical Imaging
  • Radiation Oncology
  • Cancer Research

Background:

  • Micro-computed tomography (micro-CT) is a valuable tool for longitudinal studies of cancer xenografts in mice.
  • Assessing the radiation dose from serial micro-CT examinations is crucial for ensuring it does not confound experimental results, particularly tumor growth.
  • Understanding radiation exposure is vital for the ethical and scientific integrity of animal research.

Purpose of the Study:

  • To quantify the radiation dose delivered to mouse cancer xenografts during serial micro-CT imaging.
  • To evaluate the radiation dose to the pancreas in a mouse model, simulating orthotopic pancreatic tumors.
  • To determine if the radiation dose from micro-CT imaging affects tumor growth in preclinical models.

Main Methods:

  • A nude mouse model with a subcutaneous pancreatic cancer xenograft was utilized.
  • Lithium fluoride thermoluminescent dosimeters measured radiation exposure to the tumor and pancreas.
  • Ultrafast micro-CT parameters included 80 kVp, 0.26 mA, 0.156 mm slice thickness, and 60-second acquisition time, with four repeat scans.

Main Results:

  • The radiation dose to the tumor xenografts per scan was consistently low, ranging from 0.014 to 0.02 Gy (average 0.017 Gy).
  • Radiation doses to the pancreas, simulating orthotopic tumors, were also low, ranging from 0.014 to 0.018 Gy (average 0.016 Gy) per scan.
  • These findings indicate minimal radiation exposure from serial micro-CT imaging.

Conclusions:

  • Serial ultrafast micro-CT imaging in mice delivers low radiation doses.
  • The measured doses are likely below the threshold that would significantly affect tumor growth.
  • Micro-CT can be reliably used for longitudinal studies of cancer xenografts without compromising experimental outcomes.