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Connatal rickets following repeated administration of phosphate enemas in pregnancy: a case report
P Rimensberger1, G Schubiger, U Willi
1Children's Hospital, Lucerne, Switzerland.
European Journal of Pediatrics
|January 1, 1992
Insights
Maternal phosphate overload from enemas during pregnancy can cause fetal bone growth failure. This condition impairs the skeleton's calcification process in newborns.
Area of Science:
- Obstetrics and Gynecology
- Neonatology
- Pediatric Endocrinology
Background:
- Maternal nutrition significantly impacts fetal development.
- Phosphate homeostasis is crucial for skeletal mineralization.
- Enema use during pregnancy requires careful consideration due to potential systemic absorption.
Observation:
- A case of antenatal bone growth and mineralization failure in a newborn is presented.
- The mother reported repeated administration of hypertonic phosphate enemas during pregnancy due to anorexia.
- This suggests a direct link between maternal phosphate intake and fetal skeletal development.
Findings:
- Maternal phosphate overload during pregnancy can lead to impaired fetal skeletal calcification.
- Hypertonic phosphate enemas represent a potential route for significant phosphate absorption.
- The study highlights a novel cause of congenital bone disorders.
Implications:
- Clinicians should be aware of the risks associated with excessive enema use in pregnant patients.
- Further research is needed to establish safe guidelines for enema use in pregnancy.
- This case underscores the importance of maternal dietary and therapeutic practices on fetal skeletal health.
Abstract:
We present a case of antenatal failure of bone growth and mineralisation in a newborn whose anorectic mother repeatedly administered hypertonic phosphate enemas during pregnancy. Phosphate overload in pregnant women appears to impede calcification of the fetal skeleton.