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Updated: Jul 17, 2026
07:44
A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Cardiovascular changes after pulmonary embolism from injecting calcium phosphate cement
Jörg Krebs1, Nikolaus Aebli, Ben G Goss
1MEM Research Center, Institute for Surgical Technology and Biomechanics, Medical Faculty, University of Bern, Switzerland. jorg.krebs@MEMcenter.unibe.ch
Summary
Calcium phosphate (CaP) cement disintegration during pulmonary embolism causes severe cardiovascular changes. Ensuring CaP cement cohesion is crucial for safe clinical use in bone augmentation.
Area of Science:
- Biomaterials Science
- Cardiovascular Physiology
- Orthopedic Surgery
Background:
- Calcium phosphate (CaP) cements are used for bone augmentation.
- Concerns exist regarding cardiovascular risks from pulmonary cement embolism.
Purpose of the Study:
- To investigate cardiovascular changes following pulmonary embolism of CaP cement.
- To compare CaP cement with polymethylmethacrylate (PMMA) cement in an animal model.
Main Methods:
- Intravenous injection of CaP or PMMA cement in 14 sheep.
- Monitoring of cardiovascular parameters and antithrombin levels.
- Postmortem CT scanning and 3D cement reconstruction.
Main Results:
- CaP cement embolism caused a significant increase in pulmonary arterial pressure and decrease in arterial blood pressure.
- Cement disintegration was observed and linked to more severe cardiovascular reactions.
- No evidence of thromboembolism was found.
Conclusions:
- Disintegration of CaP cement in circulation poses cardiovascular risks.
- Reliable cohesion of CaP cements is essential for clinical safety in procedures like osteoporotic bone augmentation.
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