Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclic AMP and the potassium-induced vasodilation.

H Nguyen-Duong, K Brecht, G Gebert

    Pflugers Archiv : European Journal of Physiology
    |April 9, 1975
    PubMed
    Summary

    Potassium-induced vasodilation in bovine arteries does not involve cyclic adenosine monophosphate (cAMP) signaling. Increased cAMP levels were observed, but they did not mediate the relaxation response.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    About the effect of electrical irritation of the vagosympathetic nervous system on the smooth muscles of the frog lung and its influence by ions with artificial flow.

    Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere·2010
    Same author

    Examination of the cholinesterase of human blood serum.

    Deutsche medizinische Wochenschrift (1946)·2010
    Same author

    Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues.

    British journal of pharmacology·2008
    Same author

    Toxicity of statins on rat skeletal muscle mitochondria.

    Cellular and molecular life sciences : CMLS·2006
    Same author

    Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12.

    Apoptosis : an international journal on programmed cell death·2005
    Same author

    Hematopoietic transcription factor GATA-2 promotes upregulation of alpha globin and cell death in FL5.12 cells.

    Apoptosis : an international journal on programmed cell death·2005

    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Biochemistry

    Background:

    • Vascular smooth muscle relaxation is often mediated by cyclic adenosine monophosphate (cAMP).
    • The role of cAMP in potassium-induced vasodilation is not fully understood.
    • Bovine facial arteries serve as a model for studying vascular responses.

    Purpose of the Study:

    • To investigate the role of cAMP in potassium-induced vasodilation in bovine facial arteries.
    • To determine if cAMP mediates relaxation induced by changes in extracellular potassium concentration.

    Main Methods:

    • Measurement of cAMP concentration in bovine facial artery strips.
    • Assessment of vascular smooth muscle mechanical responses to varying KCl concentrations.
    • Evaluation of the effect of beta-methyldigoxin and a phosphodiesterase activator on vascular responses and cAMP levels.

    Main Results:

    • Exposure to a physiological salt solution with 10 mM KCl increased cAMP concentration in relaxed bovine facial artery strips.
    • Pretreatment with beta-methyldigoxin also led to increased cAMP levels and subsequent constriction in response to 10 mM KCl.
    • Addition of a phosphodiesterase activator did not alter the mechanical response to 10 mM KCl.

    Conclusions:

    • Cyclic adenosine monophosphate (cAMP) does not appear to mediate potassium-induced vasodilation in bovine facial arteries.
    • The observed increase in cAMP during potassium-induced relaxation may not be functionally linked to the vasodilation mechanism.

    Related Experiment Videos