Related Experiment Video
Updated: Jul 17, 2026
06:51
Film Extrusion of Crambe abyssinica/Wheat Gluten Blends
Published on: January 17, 2017
[Formulation and process optimization of formula Qiqi pellets prepared by extrusion-spheronization]
Hong-xia Chen1, Xiao-bin Jia, Yan Chen
1School of Pharmacy, Jiangsu University, Zhenjiang 212001, China. chhx2005@sohu.com
Summary
Traditional Chinese Medicine Qiqi pellets were successfully prepared using extrusion-spheronization. This method offers a simple, feasible, and effective approach for producing high-quality Chinese Herbal Medicine pellets.
Area of Science:
- Pharmaceutical Technology
- Traditional Chinese Medicine Formulation
Background:
- Traditional Chinese Medicine (TCM) often requires specific dosage forms for optimal delivery.
- Developing efficient and reproducible methods for TCM pellet preparation is crucial.
Purpose of the Study:
- To prepare Qiqi pellets, a TCM formula, utilizing the extrusion-spheronization technique.
- To determine the optimal formulation and process parameters for Qiqi pellet production.
Main Methods:
- Utilized novel extrusion-spheronization equipment for pellet preparation.
- Employed L9 (3^4) orthogonal design to study influential factors and optimize the formulation.
- Assessed micromeritic properties and product yield of the prepared pellets.
Main Results:
- Qiqi pellets produced via extrusion-spheronization exhibited spherical shapes with smooth surfaces.
- The preparation process resulted in a high product yield.
- The optimized formulation and process yielded excellent quality pellets.
Conclusions:
- Extrusion-spheronization is a suitable technique for manufacturing Chinese Herbal Medicine pellets.
- The developed preparation process is simple, feasible, and yields high-quality pellets.
- The findings warrant further investigation into this method for TCM pellet production.
