Related Experiment Video
Updated: Jul 17, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Click chemistry in CuI-zeolites: the Huisgen [3 + 2]-cycloaddition
Stefan Chassaing1, Mayilvasagam Kumarraja, Abdelkarim Sani Souna Sido
1Laboratoire de Physicochimie des Hydrocarbures, assosié au CNRS, and Laboratoire de Synthèse et Réactivité Organique, associé au CNRS, Institut de Chimie, Université L. Pasteur, 4 rue B. Pascal, 67000 Strasbourg, France.
Abstract:
[reaction: see text] CuI-exchanged solids based on zeolite materials were investigated for the first time as catalysts in organic synthesis. The catalytic potential of these materials was evaluated in the Huisgen [3 + 2]-cycloaddition. Five CuI-exchanged zeolites were examined and CuI-USY proved to be a novel and efficient heterogeneous ligand-free catalyst for this "click chemistry"-type transformation.
Related Concept Videos
Cycloaddition Reactions: Overview
Cycloaddition Reactions: MO Requirements for Thermal Activation
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene

![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)