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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
[Cortisone glaucoma: epidemiological, clinical, and therapeutic study]
M-A El Afrit1, H Mazlout, S Trojet
1Service d'Ophtalmologie, Hôpital Habib Thameur, Tunis, Tunisia. ali.elafrit@rns.tn
Journal Francais D'Ophtalmologie
|February 9, 2007
Summary
Cortisone glaucoma, a serious complication of steroid therapy, frequently affects young adults due to self-medication. Early detection is crucial to prevent severe visual impairment and the need for glaucoma surgery.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Pharmacological Complications
Context:
- Steroid therapy for chronic inflammatory diseases can lead to secondary glaucoma.
- Self-medication with topical steroids is a significant risk factor.
- Cortisone glaucoma is prevalent in regions with high rates of allergic conjunctivitis and self-medication.
Purpose:
- To analyze the epidemiological and clinical characteristics of cortisone glaucoma.
- To evaluate the functional damage and therapeutic outcomes in patients with steroid-induced glaucoma.
- To highlight the challenges in managing this condition, particularly in young adults.
Summary:
- A retrospective study of 43 eyes from 23 patients revealed that topical steroids were implicated in 15 cases and systemic steroids in 8.
- Severe visual impairment (visual acuity <1/10 in 23 eyes) and visual field abnormalities were common at initial presentation.
- Surgical intervention, including deep sclerectomy or trabeculectomy, was required in 16 eyes.
Impact:
- Cortisone glaucoma represents a significant cause of visual loss, particularly in young adults.
- The late detection of this condition contributes to severe functional damage.
- Management often necessitates surgical intervention, sometimes involving specialized implants, underscoring the severity of steroid-induced glaucoma.
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