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Lower urinary tract dysfunction in multiple sclerosis.

M E Mayo1, M P Chetner

  • 1Department of Urology, University of Washington School of Medicine, Seattle.

Urology
|January 1, 1992
PubMed
Summary
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Multiple sclerosis bladder emptying failure is often due to a hypocontractile detrusor, not just dyssynergia. This condition, combined with detrusor hyperreflexia, causes urgency and incomplete bladder emptying in patients.

Area of Science:

  • Neurology
  • Urology
  • Medical Science

Background:

  • Previous research linked multiple sclerosis (MS) bladder emptying issues to detrusor-distal sphincter dyssynergia or areflexia.
  • Understanding the precise mechanisms of bladder dysfunction in MS is crucial for effective management.

Purpose of the Study:

  • To investigate the urodynamic findings in patients with multiple sclerosis (MS).
  • To identify the primary causes of bladder emptying failure in a cohort of MS patients.

Main Methods:

  • Urodynamic evaluation was performed on 46 female and 43 male patients diagnosed with multiple sclerosis.
  • Data collected included bladder contractility, sphincter function, and patient-reported symptoms.

Main Results:

Related Experiment Videos

  • A hypocontractile detrusor was the primary cause of bladder emptying failure in 63% of MS patients.
  • Detrusor hyperreflexia was prevalent (78%) and frequently co-occurred with hypocontractility (63%).
  • Urgency incontinence was more common in females, while voiding difficulty was more prevalent in males, with reduced sensation reported by most patients.

Conclusions:

  • Failure to empty the bladder in multiple sclerosis is most commonly caused by a hypocontractile detrusor.
  • The combination of detrusor hyperreflexia and hypocontractility contributes significantly to urgency and incomplete bladder emptying symptoms in MS.