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Related Experiment Videos

Clinical studies with d-fenfluramine.

B Guy-Grand1

  • 1Service Médecine et Nutrition, Hotel Dieu Paris, France.

The American Journal of Clinical Nutrition
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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d-Fenfluramine (dF) effectively supports weight management by improving diet adherence and preventing weight regain over one year. This medication shows promise for long-term obesity management with minimal side effects.

Area of Science:

  • Pharmacology
  • Obesity Research
  • Behavioral Science

Background:

  • Obesity is a complex chronic disease requiring effective long-term management strategies.
  • Current treatments often face challenges with adherence and sustained weight loss.
  • d-Fenfluramine (dF) has been investigated for its potential role in managing obesity.

Purpose of the Study:

  • To evaluate the efficacy and safety of d-Fenfluramine (dF) in human obesity management.
  • To assess dF's impact on diet adherence, weight regain prevention, and associated conditions.

Main Methods:

  • Controlled trials were conducted to study d-Fenfluramine (15 mg twice daily) in obese patients.
  • Data on diet adherence, weight changes, and side effects were collected over a one-year period.

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Main Results:

  • d-Fenfluramine (dF) demonstrated increased adherence to dietary plans.
  • The study showed dF's efficacy in preventing weight regain when used for one year.
  • Few, mostly transient, side effects were observed during the trials.

Conclusions:

  • Long-term use of d-Fenfluramine (dF) is a potential strategy for managing obese patients.
  • dF may also offer benefits for eating symptoms and mood disorders like premenstrual syndrome and seasonal affective disorder, as well as smoking withdrawal.