Related Experiment Video
Updated: Jul 17, 2026
10:22
High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
Published on: September 2, 2009
Rate-limiting hydrodynamic resistance for controlled reagent delivery for laboratory solution preparation
Prasad Oruganti1, Miklós Gratzl
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Analytical Chemistry
|February 10, 2007
Summary
This study introduces a novel method for precise liquid handling using hydrodynamic resistance, offering controlled reagent flow for solution preparation. This technique provides results comparable to conventional methods without complex instrumentation.
Area of Science:
- * Laboratory techniques and scientific instrumentation.
- * Chemical engineering and fluid dynamics.
Background:
- * Accurate delivery of small substance quantities is crucial across research, clinical, industrial, and environmental fields.
- * Existing methods like pipettes and piston systems rely on controlled volume delivery, often requiring fine mechanical instrumentation.
Purpose of the Study:
- * To evaluate the feasibility of employing constant rate-limiting hydrodynamic resistance for controlled reagent flow.
- * To explore an alternative approach for precise solution preparation and reagent delivery in laboratory settings.
Main Methods:
- * Investigated the use of hydrodynamic resistance to regulate reagent flow.
- * Determined delivered substance amounts based on time, pressure, and flow resistance parameters.
Main Results:
- * Achieved controlled reagent flow for solution preparation using hydrodynamic resistance.
- * Obtained results comparable to traditional pipetting and motorized systems.
- * Demonstrated effectiveness without reliance on fine mechanical instrumentation.
Conclusions:
- * Hydrodynamic resistance offers a practical and effective alternative for controlled reagent delivery.
- * This method shows potential for routine laboratory use in solution preparation.
- * Simplifies liquid handling by decoupling amount delivered from precise volume measurement.
Related Concept Videos
01:27Controlled-Current Coulometry: Overview
Controlled current coulometry, also known as amperostatic coulometry, is a technique used in electrochemical analysis to measure the quantity of a substance through the controlled passage of current. It involves the application of a constant current to an electrochemical cell containing the analyte of interest. As the current flows through the cell, the analyte undergoes a redox reaction at the electrode surface, resulting in a charge transfer. By monitoring the time required for a certain...
01:18Controlled-Current Coulometry: Coulometric Titration
Coulometric titrations are a form of titrimetric analysis where the reagent is generated electrically, and its amount is evaluated based on current and generating time. The electron serves as the standard reagent. The procedure is similar to conventional titrations, such as endpoint detection.
The fundamental requirements for coulometric titrations are (1) 100% efficiency in the reagent-generating electrode reaction and (2) a stoichiometric and preferably rapid reaction between the generated...
The fundamental requirements for coulometric titrations are (1) 100% efficiency in the reagent-generating electrode reaction and (2) a stoichiometric and preferably rapid reaction between the generated...