Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sodium fluoroacetate poisoning.

Alex T Proudfoot1, Sally M Bradberry, J Allister Vale

  • 1National Poisons Information Service (Birmingham Centre), City Hospital, Birmingham, UK.

Toxicological Reviews
|February 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A characterisation of one year of enhanced enquiry follow-up from a United Kingdom poison centre.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

Postgraduate Medical Journal, the early years.

Postgraduate medical journal·2025
Same author

A 10-year retrospective review of mushroom exposures reported to the United Kingdom National Poisons Information Service between 2013 and 2022.

Clinical toxicology (Philadelphia, Pa.)·2025
Same author

Paediatric opioid poisoning in the UK: a retrospective analysis of clinical enquiries to the National Poisons Information Service.

Archives of disease in childhood·2024
Same author

Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis.

Clinical toxicology (Philadelphia, Pa.)·2023
Same author

Investigation and monitoring of heavy metal poisoning.

Journal of clinical pathology·2023
Same journal

The role of oximes in the treatment of nerve agent poisoning in civilian casualties.

Toxicological reviews·2007
Same journal

A critical reconsideration of the clinical effects and treatment recommendations for sodium channel blocking drug cardiotoxicity.

Toxicological reviews·2007
Same journal

Therapeutic drug monitoring of digoxin: impact of endogenous and exogenous digoxin-like immunoreactive substances.

Toxicological reviews·2007
Same journal

Diacetyl-induced lung disease.

Toxicological reviews·2007
Same journal

Nanotechnology and nanotoxicology: a primer for clinicians.

Toxicological reviews·2007
Same journal

Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning.

Toxicological reviews·2007
See all related articles

Sodium fluoroacetate, a potent rodenticide, causes severe poisoning by disrupting cellular metabolism and energy production. Management focuses on supportive care, as antidotes are unproven in humans.

Area of Science:

  • Toxicology
  • Biochemistry
  • Metabolic Disorders

Background:

  • Sodium fluoroacetate, introduced as a rodenticide, exhibits high toxicity to non-target mammals, birds, and insects.
  • Its use has been restricted, with current applications targeting coyotes and introduced species in Australia and New Zealand.

Purpose of the Study:

  • To elucidate the biochemical mechanisms underlying sodium fluoroacetate toxicity.
  • To describe the clinical manifestations and management of acute fluoroacetate poisoning.

Main Methods:

  • Review of existing literature on sodium fluoroacetate's mechanism of action and poisoning.
  • Analysis of metabolic pathways affected by fluoroacetate, including the tricarboxylic acid cycle and neurotransmitter synthesis.

Related Experiment Videos

Main Results:

  • Fluoroacetate disrupts cellular metabolism by forming fluorocitrate, inhibiting the tricarboxylic acid cycle and reducing ATP production.
  • Poisoning leads to lactic acidosis, ketone body accumulation, altered neurotransmitter levels (glutamate), and potential hypocalcemia.
  • Clinical symptoms include gastrointestinal distress, cardiac arrhythmias, seizures, and coma.

Conclusions:

  • Sodium fluoroacetate toxicity is primarily due to the disruption of cellular oxidative metabolism.
  • Effective antidotes for human poisoning are lacking, necessitating supportive care, including correction of hypocalcemia.