Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaplastic thyroid carcinoma: an overview.

Wendy R Cornett1, Anand K Sharma, Terry A Day

  • 1The Medical University of South Carolina, Clinical Sciences Building, Charleston, SC 29425, USA. cornettw@musc.edu

Current Oncology Reports
|February 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International consensus recommendations and alignment of terminology for the histopathological diagnosis of extranodal extension in head and neck squamous cell carcinoma: an HN-CLEAR initiative.

The Lancet. Oncology·2025
Same author

Revealing the Effect of Hindered Weak Electrostatic Interactions of the Alkane Chain Length in the Imidazolium Chloride Ionic Liquids: A Molecular Electrostatic Potential Study.

Journal of computational chemistry·2025
Same author

Efficacy of Adjuvant Radioactive Iodine Therapy in Histological Variants of DTC: A Scoping Review.

Head & neck·2025
Same author

Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma.

Frontiers in immunology·2025
Same author

Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.

Cell metabolism·2024
Same author

NRG/RTOG 0837: Randomized, phase II, double-blind, placebo-controlled trial of chemoradiation with or without cediranib in newly diagnosed glioblastoma.

Neuro-oncology advances·2023
Same journal

Revisiting the Immunological Landscape of Locoregional Therapies for Gastrointestinal Cancers: A Shift Toward Interventional Immuno-Oncology.

Current oncology reports·2026
Same journal

Anti-PD-1 Combinations: Triplets and Beyond.

Current oncology reports·2026
Same journal

Sacituzumab Tirumotecan Across Gynecologic Malignancies: One Target, Multiple Diseases.

Current oncology reports·2026
Same journal

Clusterin in Head and Neck Squamous Cell Carcinoma: Diagnostic, Prognostic, and Therapeutic Implications.

Current oncology reports·2026
Same journal

Cardiac Risk Without a Roadmap: Lack of Evidence-Based Guidance for Cardiovascular Toxicity of T-Cell Redirecting Therapies.

Current oncology reports·2026
Same journal

Current Understanding of CHIP's Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature.

Current oncology reports·2026
See all related articles

Anaplastic thyroid cancer is rare but deadly, causing over half of thyroid cancer deaths. Current treatments are limited, necessitating urgent research into new therapies like molecular-based treatments.

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Thyroid cancer accounts for approximately 1% of all new cancer diagnoses.
  • Anaplastic thyroid cancer, though less than 5% of thyroid cancers, is responsible for over 50% of thyroid cancer-related mortality.
  • The aggressive nature and rapid progression of anaplastic thyroid cancer present significant challenges for effective treatment development.

Purpose of the Study:

  • To highlight the challenges in treating anaplastic thyroid cancer.
  • To underscore the limitations of current treatment modalities.
  • To emphasize the critical need for novel therapeutic strategies.

Main Methods:

  • Review of existing literature on thyroid cancer epidemiology and treatment outcomes.
  • Analysis of the aggressive characteristics and poor prognosis associated with anaplastic thyroid cancer.

Related Experiment Videos

  • Identification of current therapeutic limitations and the exploration of emerging treatment avenues.

    • Main Results:

    • Anaplastic thyroid cancer is associated with a high mortality rate despite its low incidence.
    • Conventional treatments including radiation, chemotherapy, and surgery show limited curative potential individually.
    • Combination therapies offer marginal benefits over single-modality treatments.

    Conclusions:

    • Anaplastic thyroid cancer remains a highly aggressive and difficult-to-treat malignancy.
    • Existing treatment options are largely palliative rather than curative.
    • Further investigation into innovative, molecular-based therapies is essential for improving patient outcomes.