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Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Tension-type Headache in the Elderly.

Robert G Kaniecki1

  • 1Robert G. Kaniecki, MD University of Pittsburgh, 120 Lytton Avenue, Suite 300, Pittsburgh, PA 15213, USA. kanieckirg@upmc.edu.

Current Treatment Options in Neurology
|February 10, 2007
PubMed
Summary

Tension-type headaches are common in adults, including the elderly. Diagnosis requires excluding other conditions, but age is favorable for remission, with various management options available.

Area of Science:

  • Neurology
  • Geriatric Medicine

Background:

  • Tension-type headache is the most prevalent primary headache disorder in adults.
  • While prevalence peaks in middle age, elderly individuals frequently experience chronic or episodic tension-type headaches.
  • Secondary headache disorders can mimic tension-type headaches and are more common in older adults.

Purpose of the Study:

  • To highlight the diagnostic challenges of tension-type headache in the elderly.
  • To emphasize the need to exclude organic disease in older adults.
  • To review management strategies and prognostic factors for tension-type headache in the elderly.

Main Methods:

  • Literature review focusing on epidemiology, diagnosis, and management of tension-type headache in older adults.
  • Analysis of diagnostic criteria and differential diagnoses relevant to geriatric populations.

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  • Examination of pharmacologic and non-pharmacologic treatment options and their adaptations for the elderly.
  • Main Results:

    • Diagnosis in the elderly necessitates careful exclusion of secondary causes.
    • Effective non-pharmacologic and pharmacologic treatments exist for reducing headache frequency and severity.
    • Special dosing considerations are crucial for elderly patients.
    • Advancing age is associated with a better prognosis for headache remission.

    Conclusions:

    • Diagnosing tension-type headache in the elderly requires vigilance for secondary causes.
    • Management should be tailored, considering age-related factors and potential drug interactions.
    • Older age positively influences the prognosis for remission of tension-type headaches.