Related Experiment Video
Updated: Jul 17, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
The pathogenetic role of HLA-B27 and its subtypes
Muhammad Asim Khan1, Alessandro Mathieu, Rosa Sorrentino
1Case Western Reserve University, MetroHealth Medical Center, Division of Rheumatology, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA. mkhan@metrohealth.org <mkhan@metrohealth.org>
Abstract:
The strong association between HLA-B27 and ankylosing spondylitis has been known for more than 33 years, but the enigma of the pathogenetic role of the gene and its product has not yet been solved. Ongoing studies have produced evidence supporting different theories to explain this association, and structural and functional studies of HLA-B27 allele products at molecular level have provided information of broad and multidisciplinary value and disclosed new avenues leading to autoimmunity and immune disregulation.
Related Concept Videos
Determinants of Bacterial Pathogenicity and Virulence
Antigen Processing Pathways
MHC Class I: Presenting Endogenous...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Type I Diabetes I: Introduction
Multiple Allele Traits
