Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory cytokines.

A Cerami1

  • 1Picower Institute for Medical Research, Manhasset, New York 11030.

Clinical Immunology and Immunopathology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Tumor necrosis factor (TNF) is a cytokine that protects the host but can cause lethal shock when overproduced during severe infections. Understanding TNF

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is There More than One Erythropoietin Receptor? Can the Hematopoietic Effects of EPO Be Dissociated from the Organ-Protective Effects by Carbamylated Erythropoietin?: Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305: 239-242, 2004.

Journal of the American Society of Nephrology : JASN·2023
Same author

The unexpected pathway to the creation of the HbA1c test and the discovery of AGE's.

Journal of internal medicine·2012
Same author

The value of failure: the discovery of TNF and its natural inhibitor erythropoietin.

Journal of internal medicine·2010
Same author

Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response.

Journal of internal medicine·2008
Same author

Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise.

Kidney international·2006
Same author

Erythropoietin: a candidate compound for neuroprotection in schizophrenia.

Molecular psychiatry·2003
Same journal

Mechanisms of virus replication, persistence, and regulation of immune responses.

Clinical immunology and immunopathology·2020
Same journal

Cumulative subject index for volumes 86-89

Clinical immunology and immunopathology·1998
Same journal

D-penicillamine-induced pancreatic islet autoantibody production is independent of the immunogenetic background: a lesson from patients with Wilson's disease.

Clinical immunology and immunopathology·1998
Same journal

Characterization of gastric Na+/I- symporter of the rat.

Clinical immunology and immunopathology·1998
Same journal

CD8(+), radiosensitive T cells of parental origin, oppose cells capable of down-regulating cytotoxicity in murine acute lethal graft-versus-host disease.

Clinical immunology and immunopathology·1998
Same journal

Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus.

Clinical immunology and immunopathology·1998
See all related articles

Area of Science:

  • Immunology
  • Pathophysiology
  • Molecular Biology

Background:

  • The immune system defends the host using cytokines and humoral factors.
  • Immune overproduction of mediators can cause host injury, seen in anaphylaxis and autoimmune diseases.
  • Cachectin/tumor necrosis factor (TNF) is implicated in inflammatory states like septic shock and cachexia.

Purpose of the Study:

  • To review the biology of cachectin/tumor necrosis factor (TNF).
  • To explore the role of TNF in various pathological states.
  • To discuss potential therapeutic modulation of TNF's effects.

Main Methods:

  • Literature review of TNF's biological functions.
  • Analysis of TNF's role in inflammatory and disease processes.

Related Experiment Videos

  • Exploration of therapeutic strategies targeting TNF.

    • Main Results:

    • Cachectin/TNF mediates early inflammatory responses against microbes.
    • Excessive circulating TNF can lead to lethal shock and cachexia.
    • TNF interacts with other mediators like interleukin-1 and interferon-gamma.

    Conclusions:

    • TNF is a key cytokine in host defense and pathology.
    • Its dual role necessitates careful consideration in therapeutic interventions.
    • Modulating TNF activity offers potential treatment avenues for various diseases.