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Updated: Jul 17, 2026

Real-Time Dynamic Collection of Hippocampal Extracellular Fluid from Conscious Rats Using a Microdialysis System
Published on: October 21, 2022
Microdialysis in the management of hepatic encephalopathy
P J Hutchinson1, A Gimson, P G Al-Rawi
1Academic Department of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. pjah2@cam.ac.uk
Introduction:
Fulminant hepatic encephalopathy has a high mortality.
Methods:
This case report describes the role of cerebral microdialysis as an adjunct to the management of a 49 - year-old woman with hepatic encephalopathy secondary to a paracetamol overdose.
Results:
The application of the microdialysis technique, by detecting a very low cerebral glucose concentration in the presence of a normal plasma glucose, assisted in clinical decision making.
Conclusions:
Cerebral microdialysis, by enabling continuous on-line monitoring of substrate delivery and metabolism, may have a role in the management of patients with fulminant hepatic failure.
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