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Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Ultrasonography01:17

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called a...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...

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Related Experiment Video

Updated: Jul 17, 2026

Ultrasound Localization Microscopy for Super-Resolution Mapping of the Rodent Brain Microvasculature
10:36

Ultrasound Localization Microscopy for Super-Resolution Mapping of the Rodent Brain Microvasculature

Published on: November 14, 2025

Future developments in neurovascular ultrasound.

Stephen Meairs1, Michael G Hennerici

  • 1Department of Neurology, University of Heidelberg, Universitätsklinikum Mannheim, Mannheim, Germany.

Frontiers of Neurology and Neuroscience
|February 10, 2007
PubMed
Summary

Molecular ultrasound advances enable targeted diagnostics and gene therapy for brain diseases. Microbubbles with ligands and focused ultrasound can deliver genes non-invasively by temporarily opening the blood-brain barrier.

Related Experiment Videos

Last Updated: Jul 17, 2026

Ultrasound Localization Microscopy for Super-Resolution Mapping of the Rodent Brain Microvasculature
10:36

Ultrasound Localization Microscopy for Super-Resolution Mapping of the Rodent Brain Microvasculature

Published on: November 14, 2025

Area of Science:

  • Neuroimaging
  • Molecular Imaging
  • Gene Therapy

Background:

  • Neurovascular ultrasound is evolving with molecular approaches for diagnostics and therapy.
  • Targeted ligands on microbubbles enable precise localization of vascular injury by binding to overexpressed adhesion molecules.
  • The blood-brain barrier (BBB) presents a significant challenge for brain disease gene therapy.

Purpose of the Study:

  • To explore the potential of molecularly targeted microbubbles and ultrasound for enhanced neurovascular diagnostics.
  • To investigate the feasibility of ultrasound-mediated gene delivery to the brain using microbubbles.
  • To highlight the role of ultrasound in transiently opening the blood-brain barrier for targeted gene therapy.

Main Methods:

  • Utilizing microbubbles functionalized with targeted ligands (e.g., for integrin alphavbeta3, ICAM-1) to identify vascular injury.
  • Employing focused ultrasound to induce local cavitation and enhance gene delivery via microbubble carriers.
  • Leveraging ultrasound's ability to temporarily open the blood-brain barrier for localized and targeted gene delivery.

Main Results:

  • Demonstrated feasibility of microbubble-ultrasound-enhanced gene therapy to the brain.
  • Showcased ultrasound's capability to open the blood-brain barrier in a localized, transient, and reversible manner.
  • Highlighted the potential for more selective and less invasive gene delivery compared to traditional methods.

Conclusions:

  • Molecularly targeted microbubbles and ultrasound represent a promising advancement in neurovascular diagnostics and therapy.
  • Ultrasound-mediated gene delivery offers a targeted and minimally invasive approach for treating brain diseases.
  • Future research will focus on improving ligand attachment, imaging techniques, and optimizing ultrasound parameters for gene delivery.