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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
The Physiology of Taste01:24

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The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the diffusion of...
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Cross-reactivity00:42

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Basophil Activation Test for Allergy Diagnosis
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Grapple allergy: the grape or the apple?

Hans F Otto1, Michael S Tankersley

  • 1Department of Internal Medicine, 52nd Medical Group, Spangdahlem AB, Spangdahlem, Germany. hans.otto@spangdahlem.af.mil

International Archives of Allergy and Immunology
|February 10, 2007
PubMed
Summary

Two patients developed food allergies after eating a Grapple, a novel fruit. This highlights the need for clear food labeling for individuals with allergies.

Area of Science:

  • Allergy and Immunology
  • Food Science
  • Clinical Medicine

Background:

  • Food allergies are common, with new food products frequently entering the market.
  • Grapple(R) is a recently introduced fruit, presenting a novel potential allergen.
  • Understanding allergies to new foods is crucial for public health.

Observation:

  • Two unique cases of patients experiencing allergic reactions after consuming Grapple are presented.
  • Clinical history and diagnostic testing were used to identify the specific allergen.
  • Skin prick testing and radioallergosorbent testing were employed.

Findings:

  • Clinical evaluation and allergy testing confirmed a specific food allergy to Grapple.
  • The study identified Grapple as the causative agent for the observed allergic reactions.

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  • These findings establish the first documented cases of Grapple food allergy.
  • Implications:

    • These cases underscore the importance of accurate food labeling, particularly for novel food products.
    • Individuals with food allergies must be vigilant in identifying all component ingredients.
    • Further research into the allergenicity of new fruits is warranted.