Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pawsitive impact: How pet contact ameliorates adult inflammatory stress responses in individuals raised in an urban environment.

Brain, behavior, and immunity·2025

Same author

Efficacy of integrated social cognitive remediation vs neurocognitive remediation in schizophrenia: Results from the multicenter randomized controlled ISST (Integrated Social Cognition And Social Skills Therapy) study.

Schizophrenia research·2025

Same author

Sensori- and psychomotor abnormalities, psychopathological symptoms and functionality in schizophrenia-spectrum disorders: a network analytic approach.

Schizophrenia (Heidelberg, Germany)·2025

Same author

Anhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study.

Cognitive, affective & behavioral neuroscience·2025

Same author

Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention.

Digital health·2025

Same author

Loneliness is associated with different structural brain changes in schizophrenia spectrum disorders and major depression.

Schizophrenia research·2025

Search research articles

Related Experiment Video

Updated: May 5, 2026

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.

Andreas Meyer-Lindenberg¹, Richard E Straub, Barbara K Lipska

¹Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health (NIMH), NIH, Bethesda, MD 20892, USA.

The Journal of Clinical Investigation

|February 10, 2007

Summary

A common genetic variation in the PPP1R1B gene, which codes for Dopamine- and cAMP-regulated phosphoprotein (DARPP-32), influences cognitive function and brain structure. This finding suggests DARPP-32

More Related Videos

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Related Experiment Videos

Last Updated: May 5, 2026

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) is crucial for neuronal signaling in dopaminoceptive pathways.
Preclinical studies highlight DARPP-32's role in regulating responses to drugs and striatal function, but human data are scarce.

Purpose of the Study:

To investigate the functional role of genetic variation in the PPP1R1B gene, encoding DARPP-32, in the human brain.
To explore the association between a specific PPP1R1B haplotype and cognitive performance, brain structure, and schizophrenia risk.

Main Methods:

Human brain resequencing to identify common PPP1R1B genetic variants and haplotypes.
Cognitive testing in individuals carrying the identified haplotype.
Multimodal neuroimaging (MRI) to assess brain structure and function.
Family-based association analysis to evaluate the link with schizophrenia.

Main Results:

A frequent PPP1R1B haplotype was identified, predicting DARPP-32 mRNA expression in the human brain.
This haplotype correlated with enhanced frontostriatal cognitive performance.
Neuroimaging revealed haplotype-associated effects on neostriatal volume, activation, and prefrontal cortex functional connectivity.
The haplotype was linked to an increased risk for schizophrenia in a family-based study.

Conclusions:

Genetic variation in PPP1R1B significantly impacts a prefrontal-neostriatal system in humans.
DARPP-32 plays a key role in cognitive functions reliant on frontostriatal circuits.
PPP1R1B variation may contribute to the pathogenesis of schizophrenia.