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Related Experiment Videos

Infection and anorexia.

Güler Y Kanra1, Hasan Ozen, Ateş Kara

  • 1Division of Pediatric Infectious Diseases, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The Turkish Journal of Pediatrics
|February 13, 2007
PubMed
Summary
This summary is machine-generated.

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Anorexia, a common response to infection, likely offers evolutionary benefits. Microbial products and cytokines trigger the acute phase response, influencing appetite control centers in the brain.

Area of Science:

  • Immunology
  • Neuroscience
  • Evolutionary Biology

Background:

  • Anorexia is a common behavioral response to infectious diseases.
  • The evolutionary benefits and underlying mechanisms of anorexia during infection remain largely unknown.
  • The acute phase response (APR), triggered by microbial products, involves cytokine production that can induce anorexia.

Purpose of the Study:

  • To explore the potential evolutionary benefits of anorexia during infection.
  • To elucidate the mechanisms by which microbial products and cytokines contribute to anorexia.
  • To understand how peripheral signals interact with the central nervous system (CNS) to regulate appetite during infection.

Main Methods:

  • Review of existing literature on the acute phase response, cytokines, and appetite regulation.

Related Experiment Videos

  • Analysis of the role of microbial products and cytokines in reducing food intake.
  • Examination of the pathways through which peripheral signals may influence CNS appetite control centers.

    • Main Results:

    • Microbial products and cytokines are implicated in reducing food intake during infection.
    • Locally released cytokines may inhibit feeding via peripheral sensory fibers.
    • Peripheral signals must interact with CNS appetite control regions, and direct CNS action of these substances is also likely involved.

    Conclusions:

    • Anorexia during infection is likely an adaptive response with evolutionary benefits.
    • Cytokines and microbial products play a significant role in mediating anorexia through both peripheral and central mechanisms.
    • Understanding these pathways is crucial for comprehending host-pathogen interactions and developing therapeutic strategies.