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Bilateral primary breast lymphoma--case report
Th Vasilakaki1, A Zizi-Sermpetzoglou, E Katsamagkou
1Department of Pathology of Tzaneion General Hospital of the Piraeus, Piraeus, Greece.
European Journal of Gynaecological Oncology
|February 13, 2007
Summary
Primary breast lymphoma is rare and often mistaken for breast cancer. This case highlights a 55-year-old woman with bilateral breast lymphoma, emphasizing the need for accurate diagnosis and tailored treatment strategies.
Area of Science:
- Oncology
- Pathology
Background:
- Primary breast lymphoma is an uncommon malignancy, frequently misdiagnosed preoperatively.
- Bilateral breast lymphoma predominantly affects younger women, particularly during pregnancy or postpartum periods.
Observation:
- A 55-year-old woman presented with painless bilateral breast enlargement.
- Surgical and histological examination revealed diffuse large B-cell lymphoma, a type of non-Hodgkin's lymphoma.
- Metastasis to bilateral axillary lymph nodes was confirmed, with no evidence of disease elsewhere.
Findings:
- The neoplastic cells exhibited characteristics of large centrocytes and blast cells with plasmacytoid differentiation and immunoblasts.
- The patient underwent bilateral radical mastectomy and axillary lymph node dissection.
- The patient remained recurrence-free two years post-surgery.
Implications:
- The rarity and variable presentation of breast lymphoma complicate preoperative diagnosis and treatment planning.
- Further research into classification and standardized treatment protocols is crucial for improving prognostic accuracy.
- This case underscores the importance of considering lymphoma in the differential diagnosis of bilateral breast masses.