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Pulmonary malacoplakia.

A Kiliçgün1, A Turna, A Gürses

  • 1Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Department of Thoracic Surgery, Istanbul, Turkey. alikilicgun@mynet.com

Acta Chirurgica Belgica
|February 13, 2007
PubMed
Summary
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Malacoplakia, a rare condition, mimicked bilateral tumors in an immunocompetent 76-year-old man with type 2 diabetes. Diagnosis required biopsies revealing characteristic Michaelis-Gutmann bodies.

Area of Science:

  • Medical Case Report
  • Pathology
  • Pulmonology

Background:

  • Malacoplakia is a rare chronic granulomatous disease typically associated with bacterial infections and often seen in immunocompromised individuals.
  • Pulmonary and pleural manifestations of malacoplakia are uncommon, presenting diagnostic challenges.
  • Type 2 diabetes mellitus can be a comorbidity, though not a direct cause of malacoplakia.

Observation:

  • A 76-year-old male patient presented with bilateral pulmonary and pleural nodules.
  • Initial investigations showed no signs of immunodeficiency.
  • The patient had a history of type 2 diabetes mellitus.

Findings:

  • Biopsies of pleural, pulmonary, and diaphragmatic tissues were obtained via mini-thoracotomy.
  • Pathological examination revealed the presence of Michaelis-Gutmann inclusion bodies.

Related Experiment Videos

  • The findings led to a diagnosis of malacoplakia.

    • Implications:

    • This case highlights malacoplakia's potential to mimic malignant tumors, particularly in the lungs and pleura.
    • The diagnosis in an immunocompetent patient underscores the importance of considering rare conditions beyond typical malignancies.
    • Recognition of malacoplakia is crucial for appropriate management and to avoid misdiagnosis as cancer.