[Fish meat retarding the progression of chronic renal failure in spontaneously hypercholesterolemic rats]

To investigate the effects of different dietary proteins of fish meat and casein upon the progression of chronic renal failure (CRF) in spontaneously hypercholesterolemic (SHC) rats.

48 SHC rats of 10 weeks of age were randomly divided into four groups, and placed on diets containing 20% and 40% casein or fish protein respectively till they were 22 weeks of age. 24-hour urine collections were obtained along with measurements of systolic blood pressure and blood were drew from their tail vein evry 4 weeks. Finally, the kidneys were removed and prepared for histological and immunohistochemistry study .

Fish meat diet slowed the progression of proteinuria, renal function failure and glomerular injury compared with the control casein diet in both 20% and 40% dietary groups.

Fish meat retarded the progression of CRF in SHC rats compared with casein.