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Related Experiment Video

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Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine

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Published on: October 27, 2023

Experimental models of stress.

Vladimir K Patchev¹, Alexandre V Patchev

¹Bayer Schering Pharma, Berlin, Germany. Vladimir.Patchev@Jenapharm.de

Dialogues in Clinical Neuroscience

|February 13, 2007

Summary

This review examines experimental models for inducing stress in animals, analyzing physiological and behavioral outcomes. It highlights how stress response varies with sex and age, with potential disease modeling applications.

Area of Science:

Neuroscience
Animal Models
Stress Research

Background:

The stress response is complex, with diverse manifestations.
Understanding stress induction in laboratory animals is crucial for research.
Existing models require comprehensive analysis of their utility.

Purpose of the Study:

To provide an overview of experimental paradigms for stress induction in laboratory animals.
To analyze the appropriateness of various outcome readouts (physiological, behavioral, neurochemical, endocrine).
To explore the influence of sex and age on stress response dynamics.

Main Methods:

Review of experimental paradigms based on naturalistic stressors.
Analysis of models utilizing pharmacological challenges.

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Examination of stress induction via genomic manipulations.

Main Results:

Detailed description of key features for each stressor type.
Comprehensive analysis of physiological, behavioral, neurochemical, and endocrine changes.
Evaluation of the suitability of different outcome measures.

Conclusions:

Sex and age significantly influence the dynamics of the stress response.
Stress-inducing paradigms offer potential as models for human diseases.
Further research is needed to refine and validate these animal models for translational applications.