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Gene regulation: gene control network in development.

Smadar Ben-Tabou de-Leon1, Eric H Davidson

  • 1Division of Biology, California Institute of Technology, Pasadena, California 91125, USA. smadar@caltech.edu

Annual Review of Biophysics and Biomolecular Structure
|February 13, 2007
PubMed
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Developing organisms control gene expression using the regulatory genome, a computational network of cis-regulatory modules. This network processes inputs to produce tissue-specific outputs, crucial for embryonic development and cell specification.

Area of Science:

  • Developmental biology
  • Genomics
  • Systems biology

Background:

  • Gene expression control is fundamental for organism development.
  • Developing organisms require complex computational systems for gene regulation.
  • The regulatory genome acts as this computational device.

Purpose of the Study:

  • To explain the function of cis-regulatory modules in gene expression.
  • To demonstrate the features of developmental gene regulatory networks.
  • To illustrate information processing by regulatory sequences using a specific example.

Main Methods:

  • Review of existing literature on gene regulatory networks.
  • Analysis of the gene regulatory network governing endomesoderm specification in sea urchin embryos.

Related Experiment Videos

  • Focus on cis-regulatory modules as processing units.

    • Main Results:

    • The regulatory genome, composed of cis-regulatory modules, functions as a computational device.
    • Interconnected cis-regulatory modules form gene regulatory networks essential for cell specification.
    • These networks process vast regulatory inputs to achieve tissue-specific outputs.

    Conclusions:

    • Developmental gene regulatory networks are key to controlling gene expression.
    • Regulatory sequences within cis-regulatory modules perform complex information processing.
    • The sea urchin endomesoderm specification network serves as a model for understanding these processes.