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Updated: Jul 17, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Lipoprotein (a) and apolipoprotein (a) in primary antiphospholipid syndrome
Mirjana Bećarević1, Sandra Singh, Nada Majkić-Singh
1Institute for Medical Biochemistry, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia. bmyrjana@yahoo.co.uk
Objective:
To investigate whether lipoprotein (a) (Lp(a)) and/or apolipoprotein (a) (apo(a)) may be markers for clinical features of 37 patients with primary antiphospholipid syndrome (PAPS) and to compare with 37 age- and sex-matched controls.
Methods:
Apo(a) and Lp(a) concentrations were determined by ELISA and immunonephelometry, respectively.
Results:
Only elevated apo(a) concentrations were significant predictor for cerebrovascular insults (OR=14.399, p=0.005, 95% CI: 2.224-93.230).
Conclusion:
Considering the fact that PAPS patients with cerebrovascular insults had recurrence of cerebrovascular episodes, measurement of apo(a) concentrations will help in the follow-up of those patients and thus in the prediction of future episodes. This finding should be further investigated in a larger study in order to provide adequate therapeutic intervention.
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