Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutation-selection balance in mixed mating populations.

John K Kelly1

  • 1Department Ecology and Evolutionary Biology, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045-7534, USA. jkk@ku.edu

Journal of Theoretical Biology
|February 13, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptive transgenerational plasticity through priming in response to neighbor density in Mimulus platycalyx.

PloS one·2026
Same author

Comparative Analyses of Four Reference Genomes Reveal Exceptional Diversity and Weak Linked Selection in the Yellow Monkeyflower (Mimulus guttatus) Complex.

Molecular ecology resources·2025
Same author

Measuring natural selection on the transcriptome.

The New phytologist·2025
Same author

Are you with me? Co-occurrence tests from community ecology can identify positive and negative epistasis between inversions in Mimulus guttatus.

PloS one·2025
Same author

Editorial: The impacts of the mating system and inbreeding depression in natural plant populations and crop systems.

Frontiers in plant science·2025
Same author

Testing the evolutionary theory of inversion polymorphisms in the yellow monkeyflower (Mimulus guttatus).

Nature communications·2024
Same journal

Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

Journal of theoretical biology·2026
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
See all related articles

This study introduces a new approximation for deleterious mutations per gamete, improving computational speed and analytical insights for evolutionary biology models. It resolves conflicts in mutation-selection balance research.

Area of Science:

  • Evolutionary Biology
  • Population Genetics
  • Genomics

Background:

  • Deleterious mutations accumulate in populations, impacting fitness.
  • Understanding mutation-selection balance is crucial for evolutionary dynamics.
  • Previous models faced analytical challenges and computational limitations.

Purpose of the Study:

  • To derive an accurate approximation for the average number of deleterious mutations per gamete (Q).
  • To develop a computationally efficient model for analyzing mutation-selection balance.
  • To resolve conflicting results in previous analytical treatments of mutation-selection balance.

Main Methods:

  • Developed a generalized Poisson model for mutation counts, conditioned on selfing histories.
  • Incorporated selection acting on both zygotes and male gametes.

Related Experiment Videos

  • Analyzed models with outcrossing and self-fertilization.

    • Main Results:

    • The derived approximation for Q is accurate across various parameter sets.
    • The model offers significant increases in computational speed.
    • Provides analytical insights into genomic mutation rates (U) and selective interference.

    Conclusions:

    • The new approximation enhances the study of mutation-selection balance.
    • Gametic selection has implications for inbreeding depression and mating systems.
    • The model clarifies the role of life-cycle assumptions in mutation-selection balance outcomes.