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Updated: Jul 17, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Childhood adversity, recent life events and depression in late life
Hannie C Comijs1, Aartjan T F Beekman, Filip Smit
1Department of Psychiatry, EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands. h.comijs@vumc.nl
Background:
The study investigates whether persons who have experienced childhood adversity are more likely to develop depressive symptoms when faced with recent events.
Method:
Data were used from a population-based sample, aged 55 to 85 years (n=1887), which were not depressed at baseline. Childhood adversities and recent stressful life events were retrospectively assessed. Depressive symptoms were measured with the CES-D.
Results:
14.4% of our sample experienced adverse events during childhood (<18 yrs) and 35.4% experienced recent events. Associations of depressive symptoms were found with both, childhood adversity (OR 1.80, 95% CI 1.21-2.69) and recent life events (OR 1.42, 95% CI 1.01-2.00). The effect of recent events on depressive symptoms was not modified by childhood adversity.
Limitations:
Underreporting may be present due to unwillingness to report embarrassing events or to disclose painful memories.
Conclusions:
No evidence was found for the assumption that older persons were more vulnerable for depression in reaction to recent life events when they were exposed to childhood adversity.
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