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Published on: June 23, 2026
Discovering new inhibitors of bacterial glucosamine-6P synthase (GlmS) by docking simulations
Nicolas Floquet1, Céline Richez, Philippe Durand
1Institut de Chimie des Substances Naturelles (ICSN), UPR-2301, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Abstract:
Results of an in silico screening of a freely accessible database encompassing 50,000 commercial compounds on bacterial glucosamine-6P synthase (Glms) are described. Each product was docked with the GOLD software in a region of 20A surrounding the sugar binding site and ranked according to its score. Among the 14 best-scored molecules, three molecules exhibited good experimental inhibition properties (IC(50)=70 microM) giving a high hit rate (H.R.: 0.23). Interestingly, these molecules are predicted to interact with a protein region that forms a pocket at the interface between the two enzyme monomers, opening the route to dimerization inhibitors.
