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Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis

Richard Johnsson1, Katrin Mani, Ulf Ellervik

  • 1Organic Chemistry, Lund University, PO Box 124, SE-221 00 Lund, Sweden.

Bioorganic & Medicinal Chemistry Letters
|February 13, 2007
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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...