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Related Experiment Video

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MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
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Essential tremor: phenotypic expression in a clinical cohort.

N R Whaley1, John D Putzke, Yasuhiko Baba

  • 1Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32225, USA. whaley.nathaniel@mayo.edu

Parkinsonism & Related Disorders
|February 13, 2007
PubMed
Summary

This study analyzed essential tremor (ET) patient characteristics, finding significant variability in how individuals meet diagnostic criteria. Asymmetric disease presentation is common in essential tremor cohorts.

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Area of Science:

  • Neurology
  • Clinical Neuroscience
  • Movement Disorders

Background:

  • Essential tremor (ET) is a common neurological disorder.
  • Understanding the clinical characteristics of ET cohorts is crucial for diagnosis and research.
  • Variability in diagnostic criteria may impact patient classification.

Purpose of the Study:

  • To examine the demographic and clinical features of a large essential tremor (ET) cohort.
  • To assess the base-rate variability of commonly used diagnostic criteria for ET.
  • To characterize the prevalence of specific tremor locations and family history within the ET sample.

Main Methods:

  • A retrospective analysis of 487 consecutive patients diagnosed with essential tremor (ET).
  • Data collection included patient demographics, age of onset, family history, and tremor affected body parts.
  • Evaluation of the frequency with which patients met established ET diagnostic criteria.

Main Results:

  • The cohort (n=487) had a mean age of 71, with 53% males and a mean age of onset of 52.
  • Half of the participants reported a family history of ET, and half presented with asymmetrical disease.
  • Tremor commonly affected arms (97%), voice (62%), and head/neck (48%), with notable variability in diagnostic criterion fulfillment.

Conclusions:

  • The studied ET cohort is representative of typical clinical populations.
  • Asymmetrical disease presentation and significant base-rate variation in diagnostic criteria are characteristic of essential tremor.
  • Further research may be needed to refine ET diagnostic standards due to observed variability.