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Updated: May 3, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

T-cell responses to allergens.

Judith A Woodfolk¹

¹Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908-1355, USA. jaw4m@virginia.edu <jaw4m@virginia.edu>

The Journal of Allergy and Clinical Immunology

|February 13, 2007

Summary

This summary is machine-generated.

Understanding human allergic responses involves studying allergen-specific CD4(+) T lymphocytes. Recent research reveals the molecular signature of long-lived memory T(H)2 cells, crucial for developing new T-cell therapies.

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Area of Science:

Immunology
Allergy Research

Background:

Allergic responses are mediated by CD4(+) T lymphocytes secreting T(H)2 cytokines.
Characterizing allergen-specific T cells in humans is difficult due to their low frequency.

Purpose of the Study:

To highlight advances in characterizing allergen-specific memory T(H)2 cells.
To discuss regulatory T cell heterogeneity and mechanisms.
To review T-cell epitope mapping for vaccine development and therapy.

Main Methods:

Analysis of molecular signatures of allergen-specific memory T(H)2 cells.
Investigation of regulatory T cell properties.
T-cell epitope mapping studies.

Main Results:

Insight into the molecular signature of long-lived human memory T(H)2 cells.
Understanding of factors influencing T-cell responses to allergens.
Identification of regulatory T cell heterogeneity and potential actions.

Conclusions:

Advances in characterizing allergen-specific T cells offer new avenues for T-cell-based therapies.
Epitope mapping is relevant for understanding allergen-specific T-cell responses and peptide vaccine development.