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Hepatitis

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Updated: Jul 17, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E and the traveller.

Jane N Zuckerman¹

¹Academic Centre for Travel Medicine and Vaccines and WHO Collaborating Centre for Reference ad Training in Travel Medicine, Royal Free and University College Medical School, University College London, Royal Free Campus Rowland Hill Street, London NW3 2PF, UK.

Travel Medicine and Infectious Disease

|February 13, 2007

Summary

International travelers face underestimated risks of hepatitis E virus infection in endemic regions. Strict precautions for water and food are crucial as vaccines are still under development.

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Last Updated: Jul 17, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Area of Science:

* Infectious Diseases
* Hepatitis E Virus (HEV) Research
* Travel Medicine

Background:

* Hepatitis E virus (HEV) infection risk is often underestimated for international travelers visiting endemic areas.
* Transmission occurs enterically via contaminated water or undercooked shellfish.
* Outbreaks are common in hot climates, with zoonotic transmission significant in both endemic and developed countries.

Purpose of the Study:

* To highlight the underestimated risk of HEV infection among international travelers.
* To emphasize the severity of HEV infection, particularly in pregnant women.
* To inform about current prevention strategies and ongoing vaccine development.

Main Methods:

* Review of HEV transmission routes and clinical significance.
* Analysis of endemic regions and risk factors for travelers.
* Overview of current prophylaxis, treatment, and vaccine development status.

Main Results:

* HEV infection poses a significant, underestimated risk to travelers in endemic zones.
* The virus is transmitted through contaminated water and raw/undercooked food.
* Severe clinical outcomes, including high mortality in late pregnancy (up to 20%), are documented.

Conclusions:

* Travelers to HEV-endemic regions require strict precautions regarding water and food consumption.
* Currently, no specific prophylaxis or treatment for HEV infection is available.
* Development of vaccines, including a baculovirus-expressed viral protein vaccine in phase II/III trials, is ongoing.