Related Experiment Video
Updated: Apr 27, 2026
Investigating Single Molecule Adhesion by Atomic Force Spectroscopy
Published on: February 27, 2015
Investigation of angiotensin II type 1 receptor by atomic force microscopy with functionalized tip
Guangyong Li1, Ning Xi, Donna H Wang
1Department of Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan, USA.
Abstract:
Although membrane proteins consist of a substantial amount of the human genome and are the main drug targets, the study of cell membrane proteins in situ is complicated by the technical limitations. The recent development of atomic force microscopy (AFM) opens a new way to study the functions of cell membrane proteins in situ at the single-molecule level. A detailed procedure for investigation of angiotensin II type 1 receptor by AFM with functionalized tip is introduced in this article. Some prospective methods to improve the imaging resolution are also discussed.
More Related Videos
05:44Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy
Published on: March 6, 2017
10:06Functionalization of Atomic Force Microscope Cantilevers with Single-T Cells or Single-Particle for Immunological Single-Cell Force Spectroscopy
Published on: July 10, 2019
