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FABP2 Ala54Thr polymorphism and diabetes in Chilean elders
Cecilia Albala1, Ana Villarroel, José Luis Santos
1Public Health Nutrition Unit, Chronic Diseases & Genetic Epidemiology Research Laboratory, Institute of Nutrition and Food Technology (INTA) University of Chile, Casilla, Santiago, P.O. Box 138-1, El Libiano 5524, Chile. calbala@inta.cl
The FABP2 Ala54Thr gene variant is linked to a higher risk of type 2 diabetes in Chilean elders. Carriers of the Thr54 allele showed increased diabetes incidence over a 4-year period.
Area of Science:
- Genetics
- Endocrinology
- Geriatrics
Background:
- The FABP2 gene plays a role in fatty acid metabolism and has been implicated in insulin resistance.
- The Ala54Thr polymorphism in FABP2 is a common variant studied for its association with metabolic diseases.
Purpose of the Study:
- To determine the prevalence of FABP2 genotypes in Chilean elders.
- To investigate the association between the FABP2 Ala54Thr polymorphism and type 2 diabetes over a 4-year follow-up period.
Main Methods:
- Genotyping of the FABP2 Ala54Thr variant using PCR and RFLP.
- Measurement of glucose, insulin, lipids, and calculation of insulin resistance (HOMA).
- Logistic regression analysis to assess gene-disease associations and diabetes incidence.
Main Results:
- Genotype frequencies: Ala/Ala (30.5%), Ala/Thr (49.3%), Thr/Thr (20.2%).
- Thr54 carriers showed a higher crude odds ratio (OR) for diabetes (2.18).
- Adjusted analysis revealed a significant association between Thr54Thr genotype and diabetes (OR 2.70) and diabetes incidence (OR 3.84).
Conclusions:
- The FABP2 Ala54Thr polymorphism is associated with type 2 diabetes in Chilean elders.
- A genetic dosage effect was observed, with the Thr/Thr genotype conferring the highest risk.
- These findings highlight the role of FABP2 genetics in diabetes development in this population.
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