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Using NSAID in volume depleted children can precipitate acute renal failure

Cheri Mathews John1, Rajeev Shukla, Caroline A Jones

  • 1Department of Nephrology, Royal Liverpool Children's NHS Trust, Alder Hey, Liverpool, UK.

Archives of Disease in Childhood
|February 13, 2007
PubMed

Insights

Non-steroidal anti-inflammatory drugs (NSAID) can cause kidney damage in children with dehydration or existing kidney issues. Further research is needed to understand the true risk of NSAID renal complications in at-risk pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Pharmacology
  • Internal Medicine

Background:

  • Non-steroidal anti-inflammatory drugs (NSAID) are widely used for pain and inflammation in both inpatient and outpatient settings.
  • While generally safe in healthy children at therapeutic doses, NSAID use carries potential risks.

Observation:

  • This report details four cases of NSAID-induced renal toxicity in children admitted to a pediatric hospital.
  • These cases highlight a potential complication, particularly in vulnerable pediatric populations.

Findings:

  • Renal toxicity risk from NSAID may increase with conditions stimulating the renin-angiotensin system, such as dehydration.
  • Pre-existing chronic kidney disease also appears to heighten the risk of adverse renal events associated with NSAID use.

Implications:

  • The findings suggest a need for caution when prescribing NSAID to children with dehydration or renal compromise.
  • Further research is warranted to precisely define the risk of NSAID-related renal complications in at-risk pediatric patients.

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