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Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel

Toshiyuki Takasu1, Masashi Ukai, Shuichi Sato

  • 1Institute for Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585 Japan. toshiyuki.takasu@jp.astellas.com

The Journal of Pharmacology and Experimental Therapeutics
|February 13, 2007
PubMed

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Adrenergic antagonists, or sympatholytics, inhibit adrenoceptor activation driven by catecholamines or agonists. Based on their adrenoceptor specificity, adrenergic blockers can be categorized into two primary groups: α-adrenergic blockers (α-blockers) and β-adrenergic blockers (β-blockers). α-blockers interact with α1 and α2 subtypes of α-adrenoceptors.
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Adrenergic Agonists: Chemistry and Structure-Activity Relationship

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