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04:04
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Cisplatin-induced hyperglycemic hyperosmolar coma
R Komdeur1, J Derksen, M-C Legdeur
1Department of Internal Medicine, Medical Spectrum Twente Hospital, Enschede, the Netherlands. R.Komdeur@ziekenhuis-mst.nl
The Netherlands Journal of Medicine
|February 13, 2007
Summary
Cisplatin chemotherapy can cause severe high blood sugar and hyperosmolar events, even in patients without diabetes. This rare adverse reaction highlights the need for awareness of cisplatin
Area of Science:
- Oncology
- Endocrinology
- Pharmacology
Background:
- Cisplatin is a widely used platinum-based chemotherapy agent for various solid tumors.
- Adverse drug reactions associated with cisplatin are well-documented, but glucose dysregulation is not commonly recognized.
Observation:
- A case of severe hyperglycemic hyperosmolar derangement is presented following cisplatin treatment.
- The patient had no prior history of diabetes mellitus.
Findings:
- Cisplatin administration can precipitate significant glucose metabolism impairment.
- Hyperglycemic hyperosmolar state is a potential, albeit rare, adverse effect of cisplatin therapy.
Implications:
- Clinicians should be vigilant for glucose abnormalities in patients receiving cisplatin, especially those without pre-existing diabetes.
- Further research is warranted to elucidate the mechanisms and incidence of cisplatin-induced glucose derangement.
- Enhanced monitoring of glycemic control may be necessary during cisplatin chemotherapy.
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