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Updated: Jul 17, 2026
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil
Luzidalva Barbosa de Medeiros1, Heloísa Ramos Lacerda, Ana Maria Salustiano Cavalcanti
1Hospital das Clínicas, Departamento de Medicina Clínica, Universidade Federal de Pernambuco, Cidade Universitária, Recife, PE, Brasil.
Abstract:
To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeq Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.
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