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Updated: Jul 17, 2026
08:48
In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
Published on: November 5, 2021
Impairment of cell division of Trypanosoma cruzi epimastigotes
1Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. mazacks@utmb.edu
Memorias Do Instituto Oswaldo Cruz
|February 13, 2007
Abstract:
The mechanisms that facilitate the adaptation of Trypanosoma cruzi to two distinct hosts, insect and vertebrate, are poorly understood, in part due to the limited ability to perform gene disruption studies by homologous recombination. This report describes a developmentally-defective phenotype that resulted from integration of a drug marker adjacent to the GAPDH gene in T. cruzi.
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