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Updated: Jul 17, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

[The practicability of HLA matching].

D Böhringer¹, T Reinhard

¹Universitätsaugenklinik Freiburg, Killianstrasse 5, 79106 Freiburg, Freiburg. daniel.boehringer@uniklinik-freiburg.de

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

|February 13, 2007

Summary

Predicting waiting times for human leukocyte antigen (HLA) matching and identifying less immunogenic HLA mismatches are improving graft compatibility. These advancements make histocompatibility in penetrating keratoplasty achievable for nearly all patients.

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Published on: March 25, 2014

Area of Science:

Immunogenetics
Ophthalmology
Transplantation immunology

Context:

Human leukocyte antigen (HLA) matching is crucial for graft survival but hindered by unpredictable waiting times.
Current clinical practices face challenges in routine HLA matching acceptance.
Predictive algorithms and novel matching methods are needed to overcome these barriers.

Purpose:

To introduce new methods for improving HLA matching in clinical settings.
To address the challenge of unpredictable waiting times for histocompatible grafts.
To facilitate graft compatibility in procedures like penetrating keratoplasty.

Summary:

A new algorithm predicts waiting times for histocompatible grafts, enabling personalized risk-benefit analysis.
HLAMatchmaker identifies HLA mismatches with reduced immunogenicity, aiding patients with rare HLA phenotypes.
These combined advancements significantly enhance the feasibility of achieving histocompatibility in penetrating keratoplasty.

Impact:

Increased acceptance of HLA matching in routine clinical practice.
Improved prognosis for patients awaiting grafts by balancing waiting time and graft benefit.
Expanded access to histocompatible grafts, particularly for individuals with rare HLA types.
Near-universal success in achieving histocompatibility for penetrating keratoplasty.