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Related Experiment Video

Updated: Jul 17, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Meningococcal disease associated with an acute post-streptococcal complement deficiency.

Nikolaos Daskas¹, Katie Farmer, Richard Coward

¹Bristol Royal Hospital for Children, Bristol, UK.

Pediatric Nephrology (Berlin, Germany)

|February 13, 2007

Summary

Meningococcal disease typically results from chronic complement deficiencies. This study details a rare case in a child experiencing meningococcal disease due to a temporary complement deficiency linked to post-streptococcal glomerulonephritis.

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Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

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Last Updated: Jul 17, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

Area of Science:

Immunology
Pediatrics
Nephrology

Background:

Complement pathway protein deficiencies increase meningococcal disease risk.
Deficiencies are usually chronic, stemming from congenital issues or conditions like SLE and MPGN.

Observation:

A child presented with meningococcal disease.
The child had a transient complement deficiency.

Findings:

The transient complement deficiency was caused by post-streptococcal glomerulonephritis (PSGN).
This represents a novel cause of complement deficiency leading to meningococcal disease.

Implications:

Highlights PSGN as a potential cause of transient complement deficiency.
Suggests considering transient complement deficiencies in pediatric meningococcal disease cases.
Expands understanding of complement deficiency in infectious disease susceptibility.